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1

Natural-product-derived fragments for fragment-based ligand discovery

Over, Björn, Wetzel, Stefan, Grütter, Christian, Nakai, Yasushi, Renner, Steffen, Rauh, Daniel, Waldmann, Herbert

Journal:

Nature Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 6.12 MB

english, 2012

2

Highly Selective Cobalt-Catalyzed Hydrovinylation of Styrene

Michiel M. P. Grutters, Jarl Ivar van der Vlugt, Yuxin Pei, Allison M. Mills, Martin Lutz, Anthony L. Spek, Christian Müller, Christina Moberg, Dieter Vogt

Journal:

Advanced Synthesis & Catalysis

Année:

2009

Langue:

english

Fichier:

PDF, 328 KB

english, 2009

3

A Biomimetic Chromanol Cyclization Leading to α-Tocopherol

Christian Grütter, Emma Alonso, Antoinette Chougnet, Wolf-D. Woggon

Journal:

Angewandte Chemie

Année:

2006

Langue:

english

Fichier:

PDF, 285 KB

english, 2006

4

A Biomimetic Chromanol Cyclization Leading to α-Tocopherol

Christian Grütter, Emma Alonso, Antoinette Chougnet, Wolf-D. Woggon

Journal:

Angewandte Chemie International Edition

Année:

2006

Langue:

english

Fichier:

PDF, 285 KB

english, 2006

5

Characterization of Irreversible Kinase Inhibitors by Directly Detecting Covalent Bond Formation: A Tool for Dissecting Kinase Drug Resistance

Sabine Klüter , Dr. Jeffrey R. Simard , Dr. Haridas B. Rode, Dr. Christian Grütter, Dr. Vijaykumar Pawar, Dr. Hans C. A. Raaijmakers, Dr. Tjeerd A. Barf, Dr. Matthias Rabiller, Prof. Dr. Willem A. L.

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 702 KB

english, 2010

6

Inside Cover: Characterization of Irreversible Kinase Inhibitors by Directly Detecting Covalent Bond Formation: A Tool for Dissecting Kinase Drug Resistance (ChemBioChem 18/2010)

Sabine Klüter , Dr. Jeffrey R. Simard , Dr. Haridas B. Rode, Dr. Christian Grütter, Dr. Vijaykumar Pawar, Dr. Hans C. A. Raaijmakers, Dr. Tjeerd A. Barf, Dr. Matthias Rabiller, Prof. Dr. Willem A. L.

Journal:

Année:

2010

Fichier:

PDF, 643 KB

2010

7

Syntheses and Biological Properties of Cysteine-Reactive Epibatidine Derivatives.

Christian Che, Gregory Petit, Florence Kotzyba-Hibert, Sonia Bertrand, Daniel Bertrand, Thomas Grutter, Maurice Goeldner

Journal:

Année:

2003

Fichier:

PDF, 123 KB

2003

8

Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR

Anja Michalczyk, Sabine Klüter, Haridas B. Rode, Jeffrey R. Simard, Christian Grütter, Matthias Rabiller, Daniel Rauh

Journal:

Bioorganic & Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 723 KB

english, 2008

9

Synthesis and biological evaluation of 7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles as inhibitors of myosin light chain kinase and epidermal growth factor receptor

Haridas B. Rode, Martin L. Sos, Christian Grütter, Stefanie Heynck, Jeffrey R. Simard, Daniel Rauh

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 1.53 MB

english, 2011

10

Recombinant hirustasin: Production in yeast, crystallization, and interaction with serine proteases

Stefania Di Marco, Gabriele Fendrich, Rene Knecht, Andre Strauss, Gabriele Pohlig, Jutta Heim, John P. Priestle, Markus G. Grütter, Christian P. Sommerhoff

Journal:

Protein Science

Année:

1997

Langue:

english

Fichier:

PDF, 3.71 MB

english, 1997

11

Syntheses and biological properties of cysteine-Reactive epibatidine derivatives

Christian Che, Grégory Petit, Florence Kotzyba-Hibert, Sonia Bertrand, Daniel Bertrand, Thomas Grutter, Maurice Goeldner

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 164 KB

english, 2003

12

Structural basis and kinetics of inter- and intramolecular disulfide exchange in the redox catalyst DsbD

Rozhkova, Anna, Stirnimann, Christian U, Frei, Patrick, Grauschopf, Ulla, Brunisholz, René, Grütter, Markus G, Capitani, Guido, Glockshuber, Rudi

Journal:

The EMBO Journal

Année:

2004

Langue:

english

Fichier:

PDF, 425 KB

english, 2004

13

Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor

Koeberle, Solveigh C, Romir, Johannes, Fischer, Stefan, Koeberle, Andreas, Schattel, Verena, Albrecht, Wolfgang, Grütter, Christian, Werz, Oliver, Rauh, Daniel, Stehle, Thilo

Journal:

Nature Chemical Biology

Année:

2011

Langue:

english

Fichier:

PDF, 371 KB

english, 2011

14

Design, Synthesis, and Biological Evaluation of Novel Disubstituted Dibenzosuberones as Highly Potent and Selective Inhibitors of p38 Mitogen Activated Protein Kinase

Koeberle, Solveigh C., Fischer, Stefan, Schollmeyer, Dieter, Schattel, Verena, Grütter, Christian, Rauh, Daniel, Laufer, Stefan A.

Journal:

Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 581 KB

english, 2012

15

Structure-based design, synthesis and biological evaluation of N-pyrazole, N′-thiazole urea inhibitors of MAP kinase p38α

Matthäus Getlik, Christian Grütter, Jeffrey R. Simard, Hoang D. Nguyen, Armin Robubi, Beate Aust, Willem A.L. van Otterlo, Daniel Rauh

Journal:

European Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 1.52 MB

english, 2012

16

Structural Basis and Kinetics of DsbD-Dependent Cytochrome c Maturation

Christian U. Stirnimann, Anna Rozhkova, Ulla Grauschopf, Markus G. Grütter, Rudi Glockshuber, Guido Capitani

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 489 KB

english, 2005

17

A new structural class of serine protease inhibitors revealed by the structure of the hirustasin–kallikrein complex

Peer RE Mittl, Stefania Di Marco, Gabriele Fendrich, Gabriele Pohlig, Jutta Heim, Christian Sommerhoff, Hans Fritz, John P Priestle, Markus G Grütter

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 767 KB

english, 1997

18

Recombinant Soluble β-1,4-Galactosyltransferases Expressed in Saccharomyces cerevisiae : Purification, Characterization and Comparison with Human Enzyme

Martine Malissard, Lubor Borsig, Stefania Di Marco, Markus G. Grütter, Udo Kragl, Christian Wandrey, Eric G. Berger

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 1.10 MB

english, 1996

19

Structure of the PRYSPRY-domain: Implications for autoinflammatory diseases

Christian Grütter, Christophe Briand, Guido Capitani, Peer R.E. Mittl, Stephanie Papin, Jürg Tschopp, Markus G. Grütter

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 1.65 MB

english, 2006

20

High-resolution Structures of Escherichia coli cDsbD in Different Redox States: A Combined Crystallographic, Biochemical and Computational Study

Christian U. Stirnimann, Anna Rozhkova, Ulla Grauschopf, Rainer A. Böckmann, Rudi Glockshuber, Guido Capitani, Markus G. Grütter

Journal:

Journal of Molecular Biology

Année:

2006

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2006

21

DsbL and DsbI Form a Specific Dithiol Oxidase System for Periplasmic Arylsulfate Sulfotransferase in Uropathogenic Escherichia coli

John P.A. Grimshaw, Christian U. Stirnimann, Maurice S. Brozzo, Goran Malojcic, Markus G. Grütter, Guido Capitani, Rudi Glockshuber

Journal:

Journal of Molecular Biology

Année:

2008

Langue:

english

Fichier:

PDF, 2.16 MB

english, 2008

22

The Crystal Structure of Human Pyrin B30.2 Domain: Implications for Mutations Associated with Familial Mediterranean Fever

Christopher Weinert, Christian Grütter, Heidi Roschitzki-Voser, Peer R.E. Mittl, Markus G. Grütter

Journal:

Journal of Molecular Biology

Année:

2009

Langue:

english

Fichier:

PDF, 841 KB

english, 2009

23

Highly Selective Cobalt-Catalyzed Hydrovinylation of Styrene

Grutters, Michiel M. P., Müller, Christian, Vogt, Dieter

Journal:

Journal of the American Chemical Society

Année:

2006

Langue:

english

Fichier:

PDF, 41 KB

english, 2006

24

A new screening assay for allosteric inhibitors of cSrc

Simard, Jeffrey R, Klüter, Sabine, Grütter, Christian, Getlik, Matthäus, Rabiller, Matthias, Rode, Haridas B, Rauh, Daniel

Journal:

Nature Chemical Biology

Année:

2009

Langue:

english

Fichier:

PDF, 327 KB

english, 2009

25

Strategies for the Selective Regulation of Kinases with Allosteric Modulators: Exploiting Exclusive Structural Features

Fang, Zhizhou, Grütter, Christian, Rauh, Daniel

Journal:

ACS Chemical Biology

Année:

2013

Langue:

english

Fichier:

PDF, 3.90 MB

english, 2013

26

Targeting GSK3 from Ustilago maydis : Type-II Kinase Inhibitors as Potential Antifungals

Grütter, Christian, Simard, Jeffrey R., Mayer-Wrangowski, Svenja C., Schreier, Peter H., Pérez-Martín, José, Richters, André, Getlik, Matthäus, Gutbrod, Oliver, Braun, Christoph A., Beck, Michael E.,

Journal:

ACS Chemical Biology

Année:

2012

Langue:

english

Fichier:

PDF, 648 KB

english, 2012

27

Targeting Gain of Function and Resistance Mutations in Abl and KIT by Hybrid Compound Design

Richters, André, Ketzer, Julia, Getlik, Matthäus, Grütter, Christian, Schneider, Ralf, Heuckmann, Johannes M., Heynck, Stefanie, Sos, Martin L., Gupta, Anu, Unger, Anke, Schultz-Fademrecht, Carsten, T

Journal:

Journal of Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 4.49 MB

english, 2013

28

Selective Detection of Allosteric Phosphatase Inhibitors

Schneider, Ralf, Beumer, Claudia, Simard, Jeffrey R., Grütter, Christian, Rauh, Daniel

Journal:

Journal of the American Chemical Society

Année:

2013

Langue:

english

Fichier:

PDF, 1001 KB

english, 2013

29

Identification of Ustilago maydis Aurora Kinase As a Novel Antifungal Target

Tückmantel, Sandra, Greul, Jörg N., Janning, Petra, Brockmeyer, Andreas, Grütter, Christian, Simard, Jeffrey R., Gutbrod, Oliver, Beck, Michael E., Tietjen, Klaus, Rauh, Daniel, Schreier, Peter H.

Journal:

ACS Chemical Biology

Année:

2011

Langue:

english

Fichier:

PDF, 4.29 MB

english, 2011

30

Dibenzosuberones as p38 Mitogen-Activated Protein Kinase Inhibitors with Low ATP Competitiveness and Outstanding Whole Blood Activity

Fischer, Stefan, Wentsch, Heike K., Mayer-Wrangowski, Svenja C., Zimmermann, Markus, Bauer, Silke M., Storch, Kirsten, Niess, Raimund, Koeberle, Solveigh C., Grütter, Christian, Boeckler, Frank M., Ra

Journal:

Journal of Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 2.85 MB

english, 2013

31

Fluorescent-tagged Kinases: A New Assay System For Detecting And Screening For Allosteric Kinase Inhibitors

Simard, Jeffrey R., Getlik, Matthäus, Klüter, Sabine, Grütter, Christian, Rabiller, Matthias, Wulfert, Sabine, Ruddigkeit, Lars, Pawar, Vijaykumar, Rode, Haridas B., Rauh, Daniel

Journal:

Biophysical Journal

Année:

2009

Langue:

english

Fichier:

PDF, 52 KB

english, 2009

32

Structural Characterization of the RLCK Family Member BSK8: A Pseudokinase with an Unprecedented Architecture

Grütter, Christian, Sreeramulu, Shivakumar, Sessa, Guido, Rauh, Daniel

Journal:

Journal of Molecular Biology

Année:

2013

Langue:

english

Fichier:

PDF, 1.50 MB

english, 2013

33

Identification of Type II and III DDR2 Inhibitors

Richters, André, Nguyen, Hoang D., Phan, Trang, Simard, Jeffrey R., Grütter, Christian, Engel, Julian, Rauh, Daniel

Journal:

Journal of Medicinal Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 2.57 MB

english, 2014

34

Nicotinic Acetylcholine Receptor Labeled with a Tritiated, Photoactivatable Agonist: A New Tool for Investigating the Functional, Activated State †

Kotzyba-Hibert, Florence, Kessler, Pascal, Zerbib, Vincent, Grutter, Thomas, Bogen, Christian, Takeda, Kenneth, Hammadi, Akli, Knerr, Laurent, Goeldner, Maurice

Journal:

Bioconjugate Chemistry

Année:

1997

Langue:

english

Fichier:

PDF, 399 KB

english, 1997

35

Targeting Drug Resistance in EGFR with Covalent Inhibitors - a Structure-Based Design Approach

Engel, Julian, Richters, Andre, Getlik, Matthäus, Tomassi, Stefano, Keul, Marina, Termathe, Martin, Lategahn, Jonas, Becker, Christian, Mayer-Wrangowski, Svenja, Grütter, Christian, Uhlenbrock, Niklas

Journal:

Journal of Medicinal Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 2.01 MB

english, 2015

36

High-sensitivity phase-contrast tomography of rat brain in phosphate buffered saline

Pfeiffer, Franz, David, Christian, Bunk, Oliver, Poitry-Yamate, Carole, Grütter, Rolf, Müller, Bert, Weitkamp, Timm

Journal:

Journal of Physics Conference Series

Année:

2009

Langue:

english

Fichier:

PDF, 949 KB

english, 2009

37

Structures of designed armadillo-repeat proteins show propagation of inter-repeat interface effects

Reichen, Christian, Madhurantakam, Chaithanya, Hansen, Simon, Grütter, Markus G., Plückthun, Andreas, Mittl, Peer R. E.

Journal:

Acta Crystallographica Section D Structural Biology

Année:

2016

Langue:

english

Fichier:

PDF, 1.15 MB

english, 2016

38

Fluorophore Labeled Kinase Detects Ligands That Bind within the MAPK Insert of p38α Kinase

Getlik, Matthäus, Simard, Jeffrey R., Termathe, Martin, Grütter, Christian, Rabiller, Matthias, van Otterlo, Willem A. L., Rauh, Daniel, Jung, Manfred

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 1.59 MB

english, 2012